Invitrogen™ LRP5 Monoclonal Antibody (2B11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA517113

Catalog No. PIMA517113

Description

MA5-17113 targets LRP5 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17113 immunogen is purified recombinant fragment of human LRP5 expressed in E. Coli. MA5-17113 detects LRP5 which has a predicted molecular weight of approximately 179kDa.

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

Specifications

• Antigen: LRP5
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O75197
• Gene Symbols: LRP5
• Immunogen: Purified recombinant fragment of human LRP5 expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 2B11
• Conjugate: Unconjugated
• Gene: LRP5
• Gene Alias: BMND1; EVR1; EVR4; HBM; HGNC:6697; LDL receptor related protein 5; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LR3; Lrp5; LRP-5; LRP7; LRP-7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 4041
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid