Invitrogen™ LRP5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587357

Catalog No. PIPA587357

Description

Positive Samples: Mouse liver, Rat liver; Cellular Location: Endoplasmic reticulum, Membrane, Single-pass type I membrane protein Immunogen sequence: YAGANGPFPH EYVSGTPHVP L.

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

Specifications

• Antigen: LRP5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRP5
• Gene Alias: BMND1; EVR1; EVR4; HBM; HGNC:6697; LDL receptor related protein 5; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LR3; Lrp5; LRP-5; LRP7; LRP-7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16973, 293649
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.69 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q91VN0
• Gene Symbols: LRP5
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human LRP5 (NP_0023262).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat, Rat
• Product Type: Antibody
• Isotype: IgG