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Invitrogen™ LRP6 Monoclonal Antibody (255302)
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Catalog No. PIMA523950
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100 μg
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Catalog No. Quantity
PIMA523950 100 μg
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Catalog No. PIMA523950 Supplier Invitrogen™ Supplier No. MA523950
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Description

Mouse Monoclonal Antibody

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRP6
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 255302
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene LRP6
Gene Accession No. O75581
Gene Alias ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; Gw; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; lpr6; LRP6; LRP-6; ska>m26Jus>; ska26; skax26; STHAG7
Gene Symbols LRP6
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human LRP-6 Ala20-Pro1368.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4040
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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