Invitrogen™ LRP6 Monoclonal Antibody (290913)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523995

Catalog No. PIMA523995

Description

In direct ELISAs, this antibody shows approximately 50-60% cross-reactivity with recombinant human (rh) LRP-6 and no cross-reactivity with rhLDL R. Reconstitute at 0.5 mg/mL in sterile PBS.

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Specifications

• Antigen: LRP6
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O88572
• Gene Symbols: LRP6
• Immunogen: CHO-derived recombinant mouse LRP-6 Met1-Pro1368.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 290913
• Conjugate: Unconjugated
• Gene: LRP6
• Gene Alias: ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; Gw; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; lpr6; LRP6; LRP-6; ska>m26Jus>; ska26; skax26; STHAG7
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 16974
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized