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Invitrogen™ LRP6 Monoclonal Antibody (A5E7)
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Catalog No. PIMA542555
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100 μL
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PIMA542555 100 μL
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Catalog No. PIMA542555 Supplier Invitrogen™ Supplier No. MA542555
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Description

Mouse Monoclonal Antibody

Positive Control: Hela cell lysates, human colon tissue. Subcellular Location: Endoplasmic reticulum, Cell membrane, Membrane raft.

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRP6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone A5E7
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene LRP6
Gene Accession No. O75581
Gene Alias ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; Gw; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; lpr6; LRP6; LRP-6; ska>m26Jus>; ska26; skax26; STHAG7
Gene Symbols LRP6
Host Species Mouse
Immunogen Recombinant protein within human LRP6 aa 100-300.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4040
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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