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Invitrogen™ LRP6 Polyclonal Antibody
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Catalog No. PIPA589161
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100 μL
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PIPA589161 100 μL
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Catalog No. PIPA589161 Supplier Invitrogen™ Supplier No. PA589161
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: APLLLYANRR DLRLVDATNG KENATIVVGG LEDAAAVDFV FSHGLIYWSD VSEEAIKRTE FNKTESVQNV VVSGLLSPDG LACDWLGEKL YWTDSETNRI EVSNLDGSLR KVLFWQELDQ PRAIALDPSS G; Positive Samples: Mouse liver; Cellular Location: Endoplasmic reticulum, Membrane, Single-pass type I membrane protein.

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRP6
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene LRP6
Gene Accession No. O75581, O88572
Gene Alias ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; Gw; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; lpr6; LRP6; LRP-6; ska>m26Jus>; ska26; skax26; STHAG7
Gene Symbols LRP6
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human LRP6 (NP_0023272).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16974, 4040
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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