Invitrogen™ LRP6 Recombinant Rabbit Monoclonal Antibody (6Y9J1)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551445

Catalog No. FEMA551445

Description

Immunogen sequence: CSHLCLAVPV GGFVCGCPAH YSLNADNRTC SAPTTFLLFS QKSAINRMVI DEQQSPDIIL PIHSLRNVRA IDYDPLDKQL YWIDSRQNMI RKAQEDGSQG F.

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Specifications

• Antigen: LRP6
• Classification: Recombinant Monoclonal
• Concentration: 0.85 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O75581, O88572
• Gene Symbols: LRP6
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human LRP6 (NP_002327.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 6Y9J1
• Conjugate: Unconjugated
• Gene: LRP6
• Gene Alias: ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; Gw; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; lpr6; LRP6; LRP-6; ska>m26Jus>; ska26; skax26; STHAG7
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16974, 312781, 4040
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG