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Invitrogen™ LRRC23 Polyclonal Antibody
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Catalog No. PIPA531878
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100 μL
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PIPA531878 100 μL
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Catalog No. PIPA531878 Supplier Invitrogen™ Supplier No. PA531878
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: IMR32. Predicted reactivity: Human (99%), Mouse (84%), Rat (82%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The LRRC23 (Leucine-Rich Repeat Containing 23) gene encodes a protein that is an evolutionarily conserved component of the radial spoke complex in sperm flagella. It is located on human chromosome 12. The LRRC23 protein interacts with radial spoke head proteins such as RSPH3A and RSPH3B, crucial for the structural integrity and proper function of the radial spokes, which are essential for flagellar motility. Mutations or deficiencies in LRRC23 have been linked to male infertility, specifically causing asthenozoospermia, characterized by reduced sperm motility. Studies have identified various mutations in LRRC23 that result in disorganized radial spokes and impaired sperm motility, leading to infertility.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRRC23
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene LRRC23
Gene Accession No. Q53EV4
Gene Alias 4921537K05Rik; B7; leucine rich protein, B7; leucine rich repeat containing 23; leucine-rich protein B7; Leucine-rich repeat-containing protein 23; LRPB7; LRRC23; neuron-specific enolase
Gene Symbols LRRC23
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human LRRC23. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10233
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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