Invitrogen™ LRRC25 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106995

Catalog No. PIPA5106995

Description

LRRC25 Polyclonal Antibody for Western Blot

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. [UniProt].

Specifications

• Antigen: LRRC25
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRC25
• Gene Alias: leucine rich repeat containing 25; leucine-rich repeat-containing protein 25; LRRC25; MAPA; monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein; UNQ6169/PRO20174
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 126364
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q8N386
• Gene Symbols: LRRC25
• Immunogen: Synthetic peptide directed towards the N terminal region of human LRRC25.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov