Invitrogen™ LRRC33 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523822

Catalog No. PIPA523822

Description

LRRC33 Polyclonal Antibody for Western Blot, IHC (P)

LRRC33 is a key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. It associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. It is able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta and controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).

Specifications

• Antigen: LRRC33
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NRROS
• Gene Alias: E430025L02Rik; ELLP3030; Garpl1; leucine rich repeat containing 33; leucine-rich repeat-containing protein 33; Leucine-rich repeat-containing protein 33^; Lrcc33; Lrrc33; negative regulator of reactive oxygen species; Nrros; RGD1310771; Transforming growth factor beta activator LRRC33; UNQ3030; UNQ3030/PRO9833
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 375387
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q86YC3
• Gene Symbols: NRROS
• Immunogen: KLH conjugated synthetic peptide between 611-640 amino acids from the C-terminal region of human LRRC33.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG