Invitrogen™ LRRC4 Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547686

Catalog No. PIPA547686

Description

In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human LRRC3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.

Specifications

• Antigen: LRRC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lrrc4
• Gene Alias: BAG; brain tumor associated protein LRRC4; brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4; LRRC4-like protein; MBAG1; NAG14; Nasopharyngeal carcinoma-associated gene 14 protein; netrin-G2 ligand; NGL-2; NLG2; NLG-2; protein NGL-2; UNQ554/PRO1111
• Host Species: Sheep
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64101
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9HBW1
• Gene Symbols: Lrrc4
• Immunogen: CHO-derived recombinant human LRRC4 Ala39-Lys527.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG