Invitrogen™ LRRC4 Polyclonal Antibody

Catalog No.	Quantity
PIPA587809	100 μL

Catalog No. PIPA587809 Supplier Invitrogen™ Supplier No. PA587809

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LIVFYKLRKR HQQRSTVTAA RTVEIIQVDE DIPAATSAAA TAAPSGVSGE GAVVLPTIHD HINYNTYKPA HGAHWTENSL GNSLHPTVTT ISEPYIIQTH TKDKVQETQI; Positive Samples: U-87MG, U-251MG, K-562, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell junction, Membrane, Single-pass type I membrane protein, postsynaptic cell membrane, synapse.

The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.

Specifications

• Antigen: LRRC4
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2.07 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Lrrc4
• Gene Accession No.: Q45R42, Q99PH1, Q9HBW1
• Gene Alias: BAG; brain tumor associated protein LRRC4; brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4; LRRC4-like protein; MBAG1; NAG14; Nasopharyngeal carcinoma-associated gene 14 protein; netrin-G2 ligand; NGL-2; NLG2; NLG-2; protein NGL-2; UNQ554/PRO1111
• Gene Symbols: Lrrc4
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 544-653 of human LRRC4 (NP_0714261).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 192198, 64101, 641521
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG