Invitrogen™ LRRC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587809

Catalog No. PIPA587809

Description

Immunogen sequence: LIVFYKLRKR HQQRSTVTAA RTVEIIQVDE DIPAATSAAA TAAPSGVSGE GAVVLPTIHD HINYNTYKPA HGAHWTENSL GNSLHPTVTT ISEPYIIQTH TKDKVQETQI; Positive Samples: U-87MG, U-251MG, K-562, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell junction, Membrane, Single-pass type I membrane protein, postsynaptic cell membrane, synapse.

The LRRC4 gene encodes the protein leucine-rich repeat-containing protein 4, also known as NGL-1, which is involved in neural development and cellular communication. LRRC4 is a member of the leucine-rich repeat (LRR) protein family, characterized by its ability to mediate protein-protein interactions through its LRR domains. This protein is predominantly expressed in the nervous system and plays a crucial role in neuronal growth, synapse formation, and signal transduction pathways essential for brain development and function. LRRC4 contributes to cell adhesion, growth cone guidance, and synaptic plasticity, influencing the formation and maintenance of neural circuits. Its dysregulation has been linked to neurodevelopmental disorders, highlighting its importance in cognitive functions and neurological health. Additionally, LRRC4 is implicated in cancer biology, where it may act as a tumor suppressor, modulating cellular proliferation and migration. Research continues to explore LRRC4's interactions and regulatory mechanisms, offering insights into potential therapeutic applications for neurological diseases and cancer.

Specifications

• Antigen: LRRC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lrrc4
• Gene Alias: BAG; brain tumor associated protein LRRC4; brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4; LRRC4-like protein; MBAG1; NAG14; Nasopharyngeal carcinoma-associated gene 14 protein; netrin-G2 ligand; NGL-2; NLG2; NLG-2; protein NGL-2; UNQ554/PRO1111
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192198, 64101, 641521
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q45R42, Q99PH1, Q9HBW1
• Gene Symbols: Lrrc4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 544-653 of human LRRC4 (NP_0714261).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG