Invitrogen™ LRRC4C Monoclonal Antibody (1G5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522402

Catalog No. PIMA522402

Description

Peptide Sequence: AVMLVIFYKM RKQHHRQNHH APTRTVEIIN VDDEITGDTP MESHLPMPAI EHEHLNHYNS YKSPFNHTTT VNTINSIHSS VHEPLLIRMN SKDNVQETQI.

Leucine-rich repeat-containing 4C (LRRC4C), also known as Netrin-G ligand 2 (NGL-2), is a gene highlighted for its expression in the nervous system, particularly the brain. It is a member of the leucine-rich repeat superfamily, which plays a significant role in cell adhesion and signaling pathways critical for synaptic connectivity and neuronal development. LRRC4C is involved in neural processes such as axon guidance and synapse formation, aiding in the establishment of functional neural circuits. Additionally, research has suggested that LRRC4C may function as a tumor suppressor, particularly in gliomas, indicating its potential role in neuro-oncological disorders. Variations or deletions in this gene have been linked to neurodevelopmental disorders, demonstrating its importance in normal brain function and development. Furthermore, LRRC4C's expression patterns and associations with cancer also suggest its potential as a prognostic marker in clinical settings.

Specifications

• Antigen: LRRC4C
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9HCJ2
• Gene Symbols: LRRC4C
• Immunogen: LRRC4C (NP_065980.1, 541 a.a. ~ 640 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 1G5
• Conjugate: Unconjugated
• Gene: LRRC4C
• Gene Alias: 6430556C10Rik; KIAA1580; leucine rich repeat containing 4C; leucine-rich repeat-containing protein 4C; Lrrc4c; Netrin-G1 ligand; NGL1; NGL-1; RGD1311013; UNQ292/PRO331
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 57689
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid