Invitrogen™ LRRC4C Monoclonal Antibody (755720)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524363

Catalog No. PIMA524363

Description

In direct ELISAs, no cross-reactivity with recombinant human (rh) LRRC4 or rhNGL-3/LRRC4B is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Leucine-rich repeat-containing 4C (LRRC4C), also known as Netrin-G ligand 2 (NGL-2), is a gene highlighted for its expression in the nervous system, particularly the brain. It is a member of the leucine-rich repeat superfamily, which plays a significant role in cell adhesion and signaling pathways critical for synaptic connectivity and neuronal development. LRRC4C is involved in neural processes such as axon guidance and synapse formation, aiding in the establishment of functional neural circuits. Additionally, research has suggested that LRRC4C may function as a tumor suppressor, particularly in gliomas, indicating its potential role in neuro-oncological disorders. Variations or deletions in this gene have been linked to neurodevelopmental disorders, demonstrating its importance in normal brain function and development. Furthermore, LRRC4C's expression patterns and associations with cancer also suggest its potential as a prognostic marker in clinical settings.

Specifications

• Antigen: LRRC4C
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9HCJ2
• Gene Symbols: LRRC4C
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human NGL-1/LRRC4C Gln45-Lys527 (predicted).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: 755720
• Conjugate: Unconjugated
• Gene: LRRC4C
• Gene Alias: 6430556C10Rik; KIAA1580; leucine rich repeat containing 4C; leucine-rich repeat-containing protein 4C; Lrrc4c; Netrin-G1 ligand; NGL1; NGL-1; RGD1311013; UNQ292/PRO331
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 57689
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized