Invitrogen™ LRRC4C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590507

Catalog No. PIPA590507

Description

Immunogen sequence: PFSYFSTVTV ETMEPSQDEA RTTDNNVGPT PVVDWETTNV TTSLTPQSTR STEKTFTIPV TDINSGIPGI D; Positive Samples: Rat eye; Cellular Location: Cell junction, Single-pass type I membrane protein, postsynaptic cell membrane, synapse.

Leucine-rich repeat-containing 4C (LRRC4C), also known as Netrin-G ligand 2 (NGL-2), is a gene highlighted for its expression in the nervous system, particularly the brain. It is a member of the leucine-rich repeat superfamily, which plays a significant role in cell adhesion and signaling pathways critical for synaptic connectivity and neuronal development. LRRC4C is involved in neural processes such as axon guidance and synapse formation, aiding in the establishment of functional neural circuits. Additionally, research has suggested that LRRC4C may function as a tumor suppressor, particularly in gliomas, indicating its potential role in neuro-oncological disorders. Variations or deletions in this gene have been linked to neurodevelopmental disorders, demonstrating its importance in normal brain function and development. Furthermore, LRRC4C's expression patterns and associations with cancer also suggest its potential as a prognostic marker in clinical settings.

Specifications

• Antigen: LRRC4C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRC4C
• Gene Symbols: LRRC4C
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 450-520 of human LRRC4C (NP_0659801).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1.01 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Alias: 6430556C10Rik; KIAA1580; leucine rich repeat containing 4C; leucine-rich repeat-containing protein 4C; Lrrc4c; Netrin-G1 ligand; NGL1; NGL-1; RGD1311013; UNQ292/PRO331
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 311236
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid