Invitrogen™ LRRC8A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA572870

Catalog No. PIPA572870

Description

LRRC8A Polyclonal Antibody for Western Blot, IHC (P), ELISA

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.

Specifications

• Antigen: LRRC8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRC8A
• Gene Alias: AGM5; KIAA1437; leucine rich repeat containing 8 family member A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat containing 8 family member A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; Lrrc8; LRRC8A; mKIAA1437; SWELL1; Swelling protein 1; UNQ221/PRO247; Volume-regulated anion channel subunit LRRC8A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 241296, 311846, 56262
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q4V8I7, Q80WG5, Q8IWT6
• Gene Symbols: LRRC8A
• Immunogen: LRRC8A antibody for a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is within amino acids 60 - 110 of LRRC8A.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG