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LRRC8A Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549209

Catalog No. PA549209


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Description

Description

Predicted to react with mouse and rat based on sequence homology.

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
Specifications

Specifications

LRRC8A
Polyclonal
Unconjugated
LRRC8A
Liquid
LRRC8A
KLH conjugated synthetic peptide between 782-810 amino acids from the C-terminal region of human LRRC8A.
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
Q8IWT6, Q80WG5
Volume-regulated anion channel subunit LRRC8A, Leucine-rich repeat-containing protein 8A, Swelling protein 1, LRRC8A, KIAA1437, LRRC8, SWELL1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
241296, 56262
Documents
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