LRRC8A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA549209

Catalog No. PA549209

Description

Predicted to react with mouse and rat based on sequence homology.

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.

Specifications

• Antigen: LRRC8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRC8A
• Gene Alias: AGM5; KIAA1437; leucine rich repeat containing 8 family member A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat containing 8 family member A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; Lrrc8; LRRC8A; mKIAA1437; SWELL1; Swelling protein 1; UNQ221/PRO247; Volume-regulated anion channel subunit LRRC8A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 241296, 56262
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q80WG5, Q8IWT6
• Gene Symbols: LRRC8A
• Immunogen: KLH conjugated synthetic peptide between 782-810 amino acids from the C-terminal region of human LRRC8A.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: Ig