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Invitrogen™ LRRK2 Monoclonal Antibody (N231B/34), FITC
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Catalog No. PIMA545642
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100 μg
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PIMA545642 100 μg
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Catalog No. PIMA545642 Supplier Invitrogen™ Supplier No. MA545642
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Description

Mouse Monoclonal Antibody

81% identical in mouse, 80% identical in rat. <30% identity with LRRK1. 10 μg/mL of MA5-45642 was sufficient for detection of LRRK2/Dardarin in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects >200kDa. This antibody was formerly sold as clone S231B-34.

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRRK2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N231B/34
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene LRRK2
Gene Accession No. Q5S007
Gene Alias 4921513O20Rik; 9330188B09Rik; augmented in rheumatoid arthritis 17; AURA17; AW561911; BC 300-268; cI-46; D630001M17Rik; DARDARIN; DKFZp434H2111; FLJ45829; Gm927; leucine rich repeat kinase 2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; Lrrk2; LRRK-2; PARK8; RIPK7; ROCO2
Gene Symbols LRRK2
Host Species Mouse
Immunogen Fusion protein amino acids 841-960 of human LRRK2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 120892, 300160
Target Species Human, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG2a
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