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Invitrogen™ LRRK2 Monoclonal Antibody (N231B/34), PerCP
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA545643
Description
81% identical in mouse, 80% identical in rat. <30% identity with LRRK1. 10 μg/mL of MA5-45643 was sufficient for detection of LRRK2/Dardarin in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects >200kDa. This antibody was formerly sold as clone S231B-34.
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
Specifications
LRRK2 | |
Monoclonal | |
1 mg/mL | |
2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4 | |
Q5S007 | |
LRRK2 | |
Fusion protein amino acids 841-960 of human LRRK2. | |
100 μg | |
Primary | |
Human, Rat | |
Antibody | |
IgG2a |
Immunohistochemistry, Western Blot, Immunocytochemistry | |
N231B/34 | |
PerCP | |
LRRK2 | |
4921513O20Rik; 9330188B09Rik; augmented in rheumatoid arthritis 17; AURA17; AW561911; BC 300-268; cI-46; D630001M17Rik; DARDARIN; DKFZp434H2111; FLJ45829; Gm927; leucine rich repeat kinase 2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; Lrrk2; LRRK-2; PARK8; RIPK7; ROCO2 | |
Mouse | |
Protein G | |
RUO | |
120892, 300160 | |
4°C | |
Liquid |
Safety and Handling
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