Invitrogen™ LRRN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552786

Catalog No. PIPA552786

Description

Immunogen sequence: NSNKTNIRFM EPLSMFCAMP PEYKGHQVKE VLIQDSSEQC LPMISHDSFP NRLNVDIGTT VFLDCRAMAE PEPEIYWVTP IGNKITVETL SDKYKLSSEG TLEISNIQIE DSGRYTCVAQ NVQGAD Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Leucine-rich repeat neuronal 1 (LRRN1) is a gene located on chromosome 3q23, which encodes a transmembrane protein belonging to the leucine-rich repeat (LRR) family. This protein plays a significant role in neural development and synaptic plasticity due to its involvement in cell-cell adhesion and signaling pathways. LRRN1 has been implicated in brain development processes, especially in synapse organization and neuronal differentiation. Its expression is primarily localized to the central nervous system, indicating its importance in neurodevelopmental functions. Research has highlighted LRRN1's potential involvement in cognitive functions, and alterations in its expression have been associated with various neurological disorders. Additionally, LRRN1 is thought to contribute to the establishment of neuronal networks by modulating interactions between neurons through extracellular matrix components. Current studies are exploring its contributions to neuropathological conditions, providing insights into its relevance in brain health and disease.

Specifications

• Antigen: LRRN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRN1
• Gene Alias: 2810047E21Rik; fibronectin type III, immunoglobulin and leucine rich repeat domains 3; FIGLER3; Kiaa1497; leucine rich repeat neuronal 1; leucine rich repeat protein 1, neuronal; leucine-rich repeat neuronal protein 1; LRN; Lrrn1; Nbla10449; Neuronal leucine-rich repeat protein 1; NLRR-1; UNQ693/PRO1338
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57633
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6UXK5
• Gene Symbols: LRRN1
• Immunogen: Recombinant protein corresponding to Human LRRN1. Recombinant protein control fragment (Product #RP-90482).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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