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Invitrogen™ LRWD1 Polyclonal Antibody
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Catalog No. PIPA590566
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100 μL
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PIPA590566 100 μL
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Catalog No. PIPA590566 Supplier Invitrogen™ Supplier No. PA590566
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QELDLSNNHL ETLPDNLGLS HLRVLRCANN QLGDVTALCQ FPKLEELSLE GNPFLTVNDN LKVSFLLPTL RKVNGKDASS TYSQVENLNR ELTSRVTAHW E Positive Samples: U-87MG, HeLa, HepG2, Jurkat, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Chromosome, Cytoplasm, Nucleus, centromere, centrosome, cytoskeleton, microtubule organizing center, telomere.

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRWD1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene LRWD1
Gene Accession No. Q8BUI3, Q9UFC0
Gene Alias 1200011O22Rik; AU042569; AW548074; CENP-33; Centromere protein 33; leucine rich repeats and WD repeat domain containing 1; leucine-rich repeat and WD repeat-containing protein 1; leucine-rich repeats and WD repeat domain containing 1; LOC304396; Lrwd1; ORCA; ORC-associated protein; Origin recognition complex-associated protein; similar to hypothetical protein DKFZp434K1815; testicular tissue protein Li 4
Gene Symbols LRWD1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Lrwd1 (NP_6908521).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 222229, 304396, 71735
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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