LSD1 / KDM1A Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™

Catalog No.	Quantity
50-199-3945	100 μL

Catalog No. 50-199-3945 Supplier Active Motif Supplier No. 39186

Description

Rabbit Polyclonal Antibody

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.

Specifications

• Antigen: LSD1 / KDM1A
• Applications: ChIP Assay, Western Blot
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
• Gene: KDM1A
• Gene Accession No.: O60341, O60907, Q6ZQ88, Q9QXE7
• Gene Alias: 1810043O07Rik; 5330429M20; AA408884; amine oxidase (flavin containing) domain 2; Aof2; BHC110; BOS_2431; BOS_26437; BRAF35-HDAC complex protein BHC110; CPRF; D4Ertd478e; EBI; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; F-box-like/WD repeat-containing protein TBL1X; Flavin-containing amine oxidase domain-containing protein 2; KDM1; KDM1A; KIAA0601; Lsd1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine demethylase 1A; lysine-specific demethylase 1; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; mKIAA0601; neuroprotective protein 3; RGD1562975; RGD1563868; RP1-184J9.1; SMAP55; TBL1; Tbl1x; transducin (beta)-like 1 X-linked; transducin (beta)-like 1X-linked; transducin beta like 1 X-linked; transducin beta-like 1; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06; zgc:158242
• Gene Symbols: KDM1A, TBL1X
• Host Species: Rabbit
• Immunogen: This antibody was raised against full-length recombinant human LSD1 / kDM1A protein.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21372, 23028, 6907, 99982
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG