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  5. Tocris Bioscience™ LSN 2463359

Tocris Bioscience™ LSN 2463359
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Catalog No. 527510
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Catalog No. Quantity
52-751-0 10 mg
52-755-0 50 mg
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Catalog No. 52-751-0 Supplier Tocris Bioscience™ Supplier No. 5275/10
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Description

Potent and selective positive allosteric modulator at mGlu5

LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908 -induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.

Specifications

Quantity 10 mg
Product Type LSN 2463359
Purity >99%
Molecular Weight (g/mol) 265.31
Inhibitors LSN 2463359

For Research Use Only

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