Tocris LSN 2463359
Potent and selective positive allosteric modulator at mGlu5
Manufacturer: Tocris 5275/50
DescriptionPotent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.
- Chemical Name: N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide
- Formula: C16H15N3O
- CAS Number: 1401031-52-4
- Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
- Purity: >99
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