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Invitrogen™ LSR Polyclonal Antibody
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Catalog No. PIPA5107162
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PIPA5107162 100 μL
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Catalog No. PIPA5107162 Supplier Invitrogen™ Supplier No. PA5107162
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Description

Rabbit Polyclonal Antibody

Sequence homology: Dog: 86%; Horse: 79%; Human: 100%; Yeast: 79%.

Lipolysis-stimulated lipoprotein receptor (LSR), encoded by the LSR gene, is a crucial component in lipid metabolism, particularly involved in the endocytosis of triglyceride-rich lipoproteins. It is typically expressed in liver and adipose tissues, playing a pivotal role in maintaining lipid and glucose homeostasis. LSR binds to lipoproteins in the presence of free fatty acids, facilitating the uptake and clearance of lipids from the bloodstream, which is significant in preventing atherosclerosis and other lipid-related disorders. The protein functions as a multi-subunit complex, which includes two isoforms, LSRα and LSRβ, each contributing to lipoprotein metabolism. Research has highlighted its involvement in metabolic processes and its potential impacts on obesity and insulin resistance. LSR has also been studied in the context of hepatic lipid accumulation, where its downregulation is associated with increased lipid deposition in the liver, suggesting its importance in preventing non-alcoholic fatty liver disease (NAFLD). Due to its central role in lipid metabolism, LSR has emerged as a potential therapeutic target for metabolic diseases and cardiovascular conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LSR
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene LSR
Gene Accession No. Q86X29
Gene Alias ILDR3; immunoglobulin-like domain containing receptor 3; lipolysis stimulated lipoprotein receptor; lipolysis stimulated receptor; lipolysis-stimulated lipoprotein receptor; Lipolysis-stimulated receptor; lipolysis-stimulated remnant; lipolysis-stimulated remnant receptor; LISCH; LISCH protein; LISCH7; Liver-specific bHLH-Zip transcription factor; liver-specific bHLH-Zip transcription factor 7; liver-specific gene on mouse chromosome 7 protein; LSR
Gene Symbols LSR
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal region of human LSR.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51599
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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