Invitrogen™ LST1 Monoclonal Antibody (LST1/02)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA110400

Catalog No. PIMA110400

Description

This antibody reacts with an extracellular epitope of LST1, an approximately 6-11 kDa protein expressed as various transmembrane or soluble forms. LST1 is found predominantly on monocytes and dendritic cells. It migrates on SDS PAGE gels as approximately 25-28 kDa molecule.

LST1 (leukocyte-specific transcript, also known as B144) is expressed in cells of myeloid/erythroid lineage (monocytes, granulocytes, dendritic cells, platelets, erythrocytes). At least 14 alternatively spliced variants (LST1/A - LST1/N) can be detected; some of them (LST1/A, B, C, G, I, K) are transmembrane cell surface-exposed forms, the other are soluble. LST1 induces production of long, thin filopodia in dendritic cells, has an inhibitory effect on lymphocyte proliferation and may have an immunomodulatory role. LST1/A is an 11 kDa transmembrane adaptor present in membrane rafts and forms spontaneously covalent homodimers. Its intracellular domain contains two tyrosine motifs, one of them being an ITIM very similar to such motifs in Siglec.

Specifications

• Antigen: LST1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: O00453
• Gene Symbols: LST1
• Immunogen: KLH-fused peptide corresponding to amino acids SSEGPDLRGRDKRGT of human LST1 (aa 66-80).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: LST1/02
• Conjugate: Unconjugated
• Gene: LST1
• Gene Alias: B144; D6S49E; DAAP-90L16.2; leukocyte specific transcript 1; leukocyte-specific transcript 1 protein; LST1; LST-1; lymphocyte antigen 117; MGC119006; MGC119007; Protein B144
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7940
• Content And Storage: 4°C, do not freeze
• Form: Liquid