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Invitrogen™ LST1 Monoclonal Antibody (LST1/02)
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Catalog No. PIMA110400
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100 μg
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Catalog No. Quantity
PIMA110400 100 μg
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Catalog No. PIMA110400 Supplier Invitrogen™ Supplier No. MA110400
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Description

Mouse Monoclonal Antibody

This antibody reacts with an extracellular epitope of LST1, an approximately 6-11 kDa protein expressed as various transmembrane or soluble forms. LST1 is found predominantly on monocytes and dendritic cells. It migrates on SDS PAGE gels as approximately 25-28 kDa molecule.

LST1 (leukocyte-specific transcript, also known as B144) is expressed in cells of myeloid/erythroid lineage (monocytes, granulocytes, dendritic cells, platelets, erythrocytes). At least 14 alternatively spliced variants (LST1/A - LST1/N) can be detected; some of them (LST1/A, B, C, G, I, K) are transmembrane cell surface-exposed forms, the other are soluble. LST1 induces production of long, thin filopodia in dendritic cells, has an inhibitory effect on lymphocyte proliferation and may have an immunomodulatory role. LST1/A is an 11 kDa transmembrane adaptor present in membrane rafts and forms spontaneously covalent homodimers. Its intracellular domain contains two tyrosine motifs, one of them being an ITIM very similar to such motifs in Siglec.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LST1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone LST1/02
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene LST1
Gene Accession No. O00453
Gene Alias B144; D6S49E; DAAP-90L16.2; leukocyte specific transcript 1; leukocyte-specific transcript 1 protein; LST1; LST-1; lymphocyte antigen 117; MGC119006; MGC119007; Protein B144
Gene Symbols LST1
Host Species Mouse
Immunogen KLH-fused peptide corresponding to amino acids SSEGPDLRGRDKRGT of human LST1 (aa 66-80).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7940
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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