Potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
Chemical Name: N-[[trans-4-[(4,5-Dihydrobenzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
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