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LXR alpha + LXR beta Rabbit anti-Human∣Mouse∣Rat, Polyclonal, Bioss
SDP

Catalog No. 501984218
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Catalog No. Quantity
50-198-4218 100 μL
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Catalog No. 50-198-4218 Supplier Bioss Supplier No. BS18451R
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Description

Rabbit Polyclonal Antibody

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activiation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiqutination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Specifications

Antigen LXR alpha + LXR beta
Applications Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NR1H2
Gene Accession No. P55055, Q13133, Q60644, Q62685, Q62755, Q9Z0Y9
Gene Alias AI194859; AU018371; liver X nuclear receptor alpha variant 1; liver X nuclear receptor beta; Liver X Receptor; Liver X receptor alpha; Liver X receptor beta; LX receptor beta; LXR; LXR alpha; LXR beta; LXRA; LXR-a; LXRalpha; LXRB; LXR-b; LXRbeta; NER; NER1; NER-I; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 2; nuclear receptor subfamily 1, group H, member 3; OR-1; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-alpha; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; Rip15; RLD1; RLD-1; steroid hormone-nuclear receptor NER; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 1; ubiquitously-expressed nuclear receptor 2; Unr; Unr1; Unr2; UR
Gene Symbols NR1H2, NR1H3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human LXR alpha + LXR beta.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10062, 22259, 22260, 58851, 58852, 7376
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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