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Invitrogen™ LXR alpha Monoclonal Antibody (PPZ0412)
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Catalog No. 418300
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Catalog No. Quantity
41-830-0 100 μL
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Catalog No. 41-830-0 Supplier Invitrogen™ Supplier No. 418300
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Description

Mouse Monoclonal Antibody

This antibody specifically recognizes human LXR alpha and cross reacts with mouse and rat LXR alpha. This antibody does not recognize human LXR beta.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LXR alpha
Applications ChIP Assay, ELISA, Gel Shift, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone PPZ0412
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Physiological saline with 0.1% sodium azide
Gene NR1H3
Gene Accession No. Q13133, Q62685, Q9Z0Y9
Gene Alias AU018371; liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR; LXR alpha; Lxra; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1
Gene Symbols NR1H3
Host Species Mouse
Immunogen Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with E.coli-expressed recombinant human LXR-alpha (164-447 aa).
Purification Method Ammonium sulfate precipitation
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10062, 22259, 58852
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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