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Invitrogen™ LXR alpha Polyclonal Antibody
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Catalog No. APPA6824
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100 μL
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APPA6824 100 μL
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Catalog No. APPA6824 Supplier Invitrogen™ Supplier No. PA116824
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Description

Rabbit Polyclonal Antibody

The target sequence has 92% sequence homology with rat and mouse, and 90% sequence homology with chicken. Suggested positive control: human liver lysate, human liver protein.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LXR alpha
Applications Western Blot
Classification Polyclonal
Concentration 1.04 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% sodium azide
Gene NR1H3
Gene Accession No. Q13133, Q9Z0Y9
Gene Alias AU018371; liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR; LXR alpha; Lxra; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1
Gene Symbols NR1H3
Host Species Rabbit
Immunogen A synthetic peptide made to an internal portion of the human LXR alpha/NR1H3 protein sequence (between residues 50-150).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10062, 22259, 397553
Target Species Human, Mouse, Monkey, Pig
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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