Invitrogen™ Ly-108 Monoclonal Antibody (292810)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA523998

Catalog No. PIMA523998

Description

In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) BLAME and rhCRACC is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.

Specifications

• Antigen: Ly-108
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q96DU3
• Gene Symbols: SLAMF6
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human NTB-A/SLAMF6 Leu28-Lys225.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: 292810
• Conjugate: Unconjugated
• Gene: SLAMF6
• Gene Alias: Activating NK receptor; CD352; KAL1; KAL1b; KALI; KALIb; Ly108; Lymphocyte antigen 108; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTBA; NTB-A; NTBA receptor; RGD1561848; SF2000; SLAM family member 6; Slamf6; UNQ6123/PRO20080
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 114836
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized