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Invitrogen™ Ly-108 Polyclonal Antibody
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Catalog No. PIPA562513
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100 μL
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PIPA562513 100 μL
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Catalog No. PIPA562513 Supplier Invitrogen™ Supplier No. PA562513
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TCSVEDADDN VSFRWEALGN TLSSQPNLTV SWDPRISSEQ DYTCIAENAV SNLSFSVSAQ KLCEDVKIQY TDT Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 52%.

Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ly-108
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLAMF6
Gene Accession No. Q96DU3
Gene Alias Activating NK receptor; CD352; KAL1; KAL1b; KALI; KALIb; Ly108; Lymphocyte antigen 108; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTBA; NTB-A; NTBA receptor; RGD1561848; SF2000; SLAM family member 6; Slamf6; UNQ6123/PRO20080
Gene Symbols SLAMF6
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Ly-108. Recombinant protein control fragment (Product #RP-101417).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114836
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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