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Invitrogen™ Ly-108 Polyclonal Antibody
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Catalog No. PIPA587823
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100 μL
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PIPA587823 100 μL
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Catalog No. PIPA587823 Supplier Invitrogen™ Supplier No. PA587823
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Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat, Mouse lung, Mouse spleen, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein Immunogen sequence: SLTPLMVNGI LGESVTLPLE FPAGEKVNFI TWLFNETSLA FIVPHETKSP EIHVTNPKQG KRLNFTQSYS LQLSNLKMED TGSYRAQIST KTSAKLSSYT LRILRQLRNI QVTNHSQLFQ NMTCELHLTC SVEDADDNVS FRWEALGNTL SSQPNLTVSW DPRISSEQDY TCIAENAVSN LSFSVSAQKL CE.

Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ly-108
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SLAMF6
Gene Accession No. Q96DU3
Gene Alias Activating NK receptor; CD352; KAL1; KAL1b; KALI; KALIb; Ly108; Lymphocyte antigen 108; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTBA; NTB-A; NTBA receptor; RGD1561848; SF2000; SLAM family member 6; Slamf6; UNQ6123/PRO20080
Gene Symbols SLAMF6
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-215 of human SLAMF6 (NP_0011716431).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114836
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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