Invitrogen™ Ly-108 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562389

Catalog No. PIPA562389

Description

Immunogen sequence: LPLEFPAGEK VNFITWLFNE TSLAFIVPHE TKSPEIHVTN PKQGKRLNFT QSYSLQLSNL KMEDTGSYRA QISTKT Highest antigen sequence identity to the following orthologs: Mouse - 50%, Rat - 50%.

Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.

Specifications

• Antigen: Ly-108
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLAMF6
• Gene Alias: Activating NK receptor; CD352; KAL1; KAL1b; KALI; KALIb; Ly108; Lymphocyte antigen 108; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTBA; NTB-A; NTBA receptor; RGD1561848; SF2000; SLAM family member 6; Slamf6; UNQ6123/PRO20080
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114836
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96DU3
• Gene Symbols: SLAMF6
• Immunogen: Recombinant protein corresponding to Human Ly-108. Recombinant protein control fragment (Product #RP-101416).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG