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  5. Tocris Bioscience™ LY 2033298

Tocris Bioscience™ LY 2033298
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Catalog No. 70275
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25 mg
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70-275 5 mg
70-272-5 25 mg
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Catalog No. 70-275 Supplier Tocris Bioscience™ Supplier No. 7027/5
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Description

Selective positive allosteric modulator of M4 receptors.

LY 2033298 is a selective positive allosteric modulator of M4 receptor (KB = 200 nM, α = 35); increases the potency of acetylcholine by 40-fold. Exhibits no effect at hM1/3/5 receptors and a small effect at hM2 (KB = 1 μM α = 3.7). Potentiates other full and partial orthosteric agonists, including Carbachol, Oxotremorine-M, and McN-A343 . Does not affect binding of antagonist NMS. Active in vivo. Antipsychotic.

α indicates the degree of allosteric enhancement when both orthosteric and allosteric sites are occupied (derived from the allosteric ternary complex model).

Specifications

Chemical Name or Material 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
CAS 886047-13-8
Quantity 5 mg
Molecular Formula C13H14ClN3O2S
Purity 98%
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