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Tocris Bioscience™ LY 404187
GSA_VAGREENER_CHOICE

Catalog No. 529710
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52-971-0 10 mg
52-975-0 50 mg
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Description

Selective AMPA receptor positive allosteric modulator

LY 404187 is a selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo. Induces neurite growth in combination with (S)-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro. Also reduces MPTP-induced toxicity in mice. Brain penetrant.

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Specifications

Chemical Name or Material N-[2-(4′-Cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CAS 211311-95-4
Quantity 10 mg
Target AMPA Receptor Modulators
Molecular Formula C19H22N2O2S
Formula Weight 342.46
Purity >98%
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