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Description
Description: The AT8 monoclonal antibody reacts with the mouse Ly-49G receptor from 129, FVB, BALB/c, C3H, CBA, SJL and A/J, but not C57Bl/6 mice. Ly49G, a member of the Ly49 family is expressed by NK cell subset. Applications Reported: The AT-8 (AT8) antibody has been reported for use in flow cytometric analysis. Applications Tested: The AT-8 (AT8) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.
Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells.
Specifications
| Ly-49G | |
| Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Q60654 | |
| Klra7 | |
| Affinity chromatography | |
| RUO | |
| 16638 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Liquid |
| Flow Cytometry | |
| AT-8 (AT8) | |
| PE | |
| Klra7 | |
| Killer cell lectin-like receptor 7; killer cell lectin-like receptor, subfamily A, member 7; Klra7; LGL-1; Ly49g; ly-49g; Ly49-g; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49G.4; Ly49g1; Ly49g2; Ly49g4; Lymphocyte antigen 49g; T-cell surface glycoprotein Ly-49G | |
| Mouse | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a κ |
Safety and Handling
WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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