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Ly-49H Mouse, anti-Mouse, R718, Clone: 3D10, BD OptiBuild™

Catalog No. BDB752019 Shop All BD Biosciences Products
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BDB752019 50 μg
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Catalog No. BDB752019 Supplier BD Biosciences Supplier No. 752019
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Description

Mouse Monoclonal Antibody

The 3D10 monoclonal antibody specifically binds to mouse Lymphocyte antigen 49H (Ly-49H| also known as Klra8 or Killer cell lectin-like receptor 8). The 3D10 antibody does not crossreact with related molecules such as Ly-49A, C, D or G2. Ly-49H is a type II transmembrane protein and a member of the Ly-49 C-type lectin multigene family of receptors expressed by NK cells. Cell surface Ly-49H is expressed by a subset of NK cells but not by NKT cells. Ly-49H is expressed by C57BL/6 and NWNA but not by BALB/c or DBA/2 mouse NK cells. Cell surface Ly-49H presents as a ∼110 kDa disfulfide-linked homodimer and associates with signaling subunits such as DAP10 and DAP12 for optimal transduction of intracellular activation signals. Crosslinking of Ly-49H with the 3D10 antibody reportedly induces NK cell cytotoxicity and cytokine production. Ly-49H recognizes the mouse cytomegalovirus m157 glycoprotein that is expressed by infected cells and is required for protection against cytomegalovirus infection.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Ly-49H
Applications Flow Cytometry
Classification Monoclonal
Clone 3D10
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Refrigerate Upon Arrival
Form Liquid
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