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  6. Invitrogen™ Ly-6C Monoclonal Antibody (HK1.4), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ Ly-6C Monoclonal Antibody (HK1.4), Functional Grade, eBioscience™, Invitrogen™
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Catalog No. 16593285
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Catalog No. 16-593-285 Supplier Invitrogen™ Supplier No. 16593285
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Description

Rat Monoclonal Antibody

The MAb HK1.4 recognizes mouse Ly-6C, a GPI-linked protein of the Ly6 family. Ly-6C is found on monocytes/macrophages, endothelial cells and granulocytes as well as a subset of lymphocytes. Some variation of expression is found on different mouse strains in regards to expression on CD4 and CD8 lymphocytes. These correlate to 2 alleles both of which are recognized by HK1.4: Ly6c.1 found on C57Bl/6 and SJL cells which results in staining of both CD4 and CD8 cells while Ly6-C.2 found on BALB/c and 3H/He results in staining of CD8, but not CD4 cells. In vitro addition with HK1.4 antibody can increase proliferation and stimulate cytokine release.

Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes (PMN or PML) because of the varying shapes of the nucleus, which is usually lobed into three segments. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes. Granulocytes or PMN are released from the bone marrow by the regulatory complement proteins.
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