Invitrogen™ Ly-6G Recombinant Rat Monoclonal Antibody (1A8)

Catalog No.	Quantity
PIMA547882	200 μg

Catalog No. PIMA547882

Supplier: Invitrogen™ MA547882

Description

Rat Recombinant Monoclonal Antibody

Specificity: Recognises the murine GPI-anchored protein Ly6G, a marker of granulocyte differentiation, maturation and, together with Ly6C, a component of the Granulocyte Receptor-1 Antigen (Gr-1). Unlike another commonly used clone, RB6-8C5, 1A8 does not bind Ly6C.

Ly6G (Lymphocyte antigen 6 complex locus G6D) is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. The Ly6G protein has a molecular weight of approximately 21-25 kDa and is expressed by myeloid derived cells in the bone marrow. Ly6G is a good marker for detection of peripheral neutrophils, monocytes and granulocytes. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. The physiological role of Ly6G remains unclear but studies have shown its involvement in anti-tumor response, and studies with neutrophils suggest that Ly6G ligation may have an inhibitory effect on local immune responses.

Specifications

• Antigen: Ly-6G
• Applications: Flow Cytometry, Functional Assay
• Classification: Recombinant Monoclonal
• Clone: 1A8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% ProClin 300
• Gene: Ly6g
• Gene Accession No.: P35461
• Gene Alias: Gr1; Gr-1; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6G
• Gene Symbols: Ly6g
• Host Species: Rat
• Immunogen: LEW/N rats immunized with 1.5x10E8 Ly-6G-transfected EL4J cells.
• Purification Method: Protein A
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 546644
• Target Species: Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ