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Invitrogen™ Ly-6G Recombinant Rat Monoclonal Antibody (1A8)
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Catalog No. PIMA547882
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200 μg
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Catalog No. Quantity
PIMA547882 200 μg
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Catalog No. PIMA547882 Supplier Invitrogen™ Supplier No. MA547882
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Description

Rat Recombinant Monoclonal Antibody

Specificity: Recognises the murine GPI-anchored protein Ly6G, a marker of granulocyte differentiation, maturation and, together with Ly6C, a component of the Granulocyte Receptor-1 Antigen (Gr-1). Unlike another commonly used clone, RB6-8C5, 1A8 does not bind Ly6C.

Ly6G (Lymphocyte antigen 6 complex locus G6D) is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. The Ly6G protein has a molecular weight of approximately 21-25 kDa and is expressed by myeloid derived cells in the bone marrow. Ly6G is a good marker for detection of peripheral neutrophils, monocytes and granulocytes. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. The physiological role of Ly6G remains unclear but studies have shown its involvement in anti-tumor response, and studies with neutrophils suggest that Ly6G ligation may have an inhibitory effect on local immune responses.
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Specifications

Antigen Ly-6G
Applications Flow Cytometry, Functional Assay
Classification Recombinant Monoclonal
Clone 1A8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Ly6g
Gene Accession No. P35461
Gene Alias Gr1; Gr-1; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6G
Gene Symbols Ly6g
Host Species Rat
Immunogen LEW/N rats immunized with 1.5x10E8 Ly-6G-transfected EL4J cells.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 546644
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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