Invitrogen™ LYAR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557444

Catalog No. PIPA557444

Description

Immunogen sequence: RELLEQISAF DNVPRKKAKF QNWMKNSLKV HNESILDQVW NIFSEASNSE PVNKEQDQRP LHPVANPHAE ISTKVPASKV KDAVEQQGEV KKNKRERKEE R Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 67%.

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal. [UniProt].

Specifications

• Antigen: LYAR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LYAR
• Gene Alias: apoptosis-related protein; cell growth-regulating nucleolar protein; hypothetical protein FLJ20425; Ly1 antibody reactive; Ly1 antibody reactive clone; Ly1 antibody reactive homolog; Ly1 antibody-reactive protein; Lyar; LYAR protein; MLZ-264; PNAS-5; protein expressed in male leptotene and zygotene spermatocytes 264; ZC2HC2; ZLYAR
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55646
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NX58
• Gene Symbols: LYAR
• Immunogen: Recombinant protein corresponding to Human LYAR. Recombinant protein control fragment (Product #RP-96673).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG