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Invitrogen™ LYAR Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5101505
Description
Antibody detects endogenous levels of total LYAR.
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal. [UniProt].
Specifications
LYAR | |
Polyclonal | |
Unconjugated | |
LYAR | |
apoptosis-related protein; cell growth-regulating nucleolar protein; hypothetical protein FLJ20425; Ly1 antibody reactive; Ly1 antibody reactive clone; Ly1 antibody reactive homolog; Ly1 antibody-reactive protein; Lyar; LYAR protein; MLZ-264; PNAS-5; protein expressed in male leptotene and zygotene spermatocytes 264; ZC2HC2; ZLYAR | |
Rabbit | |
Affinity chromatography | |
RUO | |
17089, 55646 | |
-20°C | |
Liquid |
Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q08288, Q9NX58 | |
LYAR | |
A synthesized peptide derived from human LYAR(Accession Q9NX58), corresponding to amino acid residues K250-D300. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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