Invitrogen™ LYK5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599269

Catalog No. PIPA599269

Description

Antibody detects endogenous levels of total STRAD.

LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.

Specifications

• Antigen: LYK5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STRADA
• Gene Alias: 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; LYK5; NY-BR-96; PMSE; protein kinase LYK5; serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STE20-related kinase adaptor alpha; Stlk; Strad; STRAD alpha; Strada
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 303605, 72149, 92335
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q3UUJ4, Q7RTN6, Q7TNZ6
• Gene Symbols: STRADA
• Immunogen: A synthesized peptide derived from human STRADA(Accession Q7RTN6), corresponding to amino acid residues M312-R362.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG