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Invitrogen™ LYL1 Polyclonal Antibody
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Catalog No. FEPA5145021
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100 μL
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FEPA5145021 100 μL
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Catalog No. FEPA5145021 Supplier Invitrogen™ Supplier No. PA5145021
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TAPPTLALHY HPHPFLNSVY IGPAGPFSIF PSSRLKRRPS HCELDLAEGH QPQKVA Antigen sequence identity: Mouse 91%; Rat 93%.

Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor β chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2α proteins. Lyl-1 and E2α protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL).
TRUSTED_SUSTAINABILITY

Specifications

Antigen LYL1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LYL1
Gene Accession No. P12980
Gene Alias bHLHa18; Class A basic helix-loop-helix protein 18; LYL1; Lyl-1; LYL1, basic helix-loop-helix family member; lymphoblastic leukemia associated hematopoiesis regulator 1; lymphoblastic leukemia derived sequence 1; lymphoblastic leukemia-derived sequence 1; lymphoblastomic leukemia 1; protein lyl-1
Gene Symbols LYL1
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 95-150. Recombinant protein control fragment (Product #RP-109949).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4066
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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