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Lymphotoxin-alpha/TNF-beta Antibody (3F12.2D3), PerCP, Novus Biologicals™
SDP

Catalog No. NB016204 Shop All R&D Systems Products
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NB016204 0.1 mL
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Catalog No. NB016204 Supplier Novus Biologicals Supplier No. NBP281105PCP
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Description

Rabbit Monoclonal Antibody

Lymphotoxin-alpha/TNF-beta Monoclonal specifically detects Lymphotoxin-alpha/TNF-beta in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen Lymphotoxin-alpha/TNF-beta
Applications Flow Cytometry
Classification Monoclonal
Clone 3F12.2D3
Conjugate PerCP
Dilution Flow Cytometry
Formulation PBS
Gene Alias LT, LT-alpha, lymphotoxin alpha (TNF superfamily, member 1), TNFBlymphotoxin-alpha, TNFSF1TNF-beta, tumor necrosis factor beta, Tumor necrosis factor ligand superfamily member 1
Gene Symbols LTA
Host Species Rabbit
Immunogen 3F12 was prepared by hyperimmunizing BALB/c mice with purified recombinant human LTalpha expressed in E. coli - the hybridoma clone was selected for its ability to bind LTalpha3 by ELISA. The CDRs of the antibody were grafted to the framework regions of the mice mAb 2G7 to create the chimeric version of the antibody.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Apoptosis, Asthma, Biologically Active Proteins, Cytokine Research, Immunology, Innate Immunity
Primary or Secondary Primary
Gene ID (Entrez) 4049
Test Specificity 3F12 binds to human LTalpha3 and LT-alpha-beta (with a KD of ∽0.3 nM, determined by BIACORE; ∽ 37 pM, determined by ELISA) in both its soluble homotrimeric and membrane heterotrimeric forms. LTalpha belongs to the tumor necrosis factor (TNF) superfamily and is secreted as a homo-trimer (LTalpha3), or is expressed on the cell surface in complex with LTbeta. Lymphotoxin is produced by lymphocytes and in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. LTalpha3 signaling induces target cells to upregulate many chemokines and cytokines in an NFkB-dependent manner.
Target Species Human
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG κ
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