LYPLA3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA531701

Catalog No. PIPA531701

Description

Recommended positive controls: 293T, A431, Jurkat. Predicted reactivity: Mouse (92%), Rat (91%), Dog (96%), Rhesus Monkey (100%), Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.

Specifications

• Antigen: LYPLA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLA2G15
• Gene Alias: 1-O-acylceramide synthase; 1-O-acylceramide synthase {ECO:0000303; 1-O-acylceramidesynthase; ACS; ACS {ECO:0000303; C87498; EMBL:AAH98894.1}; EMBL:AAS66767.1}; Ensembl:ENSRNOP00000026996, ECO:0000312; Group XV phospholipase A2; group XV phospholipase A2 {ECO:0000312; GXVPLA2; LCAT-like lysophospholipase; LCAT-like lysophospholipase {ECO:0000250; LLPL; LLPL {ECO:0000250; LPLA2; LPLA2 {ECO:0000303; LYPLA3; Lysophospholipase 3; lysophospholipase 3 (lysosomal phospholipase A2); lysophospholipase 3 {ECO:0000250; lysosomal phospholipase A2; lysosomal phospholipase A2 {ECO:0000303; phospholipase A2 group XV; phospholipase A2, group XV; PLA2G15; pla2g15 {ECO:0000312; PubMed:15294901, ECO:0000312; PubMed:15294901}; RGD:1302982}; UniProtKB:Q8VEB4}; UNQ341/PRO540
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23659
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.64 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8NCC3
• Gene Symbols: PLA2G15
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 217 of Human LYPLA3
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov