Invitrogen™ LZK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587700

Catalog No. PIPA587700

Description

Immunogen sequence: CWRSSEPDKG QAGPWGCCQA DAYDPCLQCR PEQYGSLDIP SAEPVGRSPD LSKSPAHNPL LENAQSSEKT EENEFSGCRS ESSLGTSHLG TPPALPRKTR PLQKSGDDSS EEEEGEVDSE VEFPRRQRPH RCISSCQSYS TFSSENFSVS DGEEGNTSDH SNSPDELADK LEDRLAEKLD DLLSQTPEIP IDISSHSDGL SDKECAVRRV KTQMSLGKLC VEERGYENPM QFEESDCDSS DGECSDATVR TNKHYSSATW; Positive Samples: BxPC-3, U-87MG, LO2, BT-474, Mouse kidney, Mouse pancreas; Cellular Location: Cytoplasm, Membrane, Peripheral membrane protein.

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.

Specifications

• Antigen: LZK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K13
• Gene Alias: C130026N12Rik; Leucine zipper-bearing kinase; LZK; Map3k13; MEKK13; mitogen activated protein kinase kinase kinase 13; mitogen-activated protein kinase kinase kinase 13; Mixed lineage kinase; MLK
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 71751, 9175
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43283, Q1HKZ5
• Gene Symbols: MAP3K13
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 500-759 of human MAP3K13 (NP_0012292461).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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