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Invitrogen™ LZTFL1 Polyclonal Antibody
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Catalog No. PIPA521573
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100 μL
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PIPA521573 100 μL
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Catalog No. PIPA521573 Supplier Invitrogen™ Supplier No. PA521573
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, IMR32, Jurkat, HeLa, mouse testis, rat testis. Predicted reactivity: Mouse (88%), Rat (90%), Rhesus Monkey (98%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

LZTFL1, also known as Leucine Zipper Transcription Factor-Like 1, is situated on the chromosomal region 3p21.3, which is frequently deleted in various cancers, including kidney cancer. It acts as a tumor suppressor by destabilizing AKT, a key protein in cell growth pathways, thus inhibiting tumor cell growth. Additionally, LZTFL1 has been implicated in the epithelial-mesenchymal transition in COVID-19, suggesting a role in viral response pathways. It is associated with Bardet-Biedl syndrome (BBS) and interacts with IFT27, a regulator of sperm flagellum formation, affecting spermatogenesis and male fertility. Knockout models show a phenotype of obesity, retinal degeneration, and abnormal cilia development, highlighting its role in normal ciliary function. The gene has two transcript isoforms and is part of a transcriptional map covering 250 kb, making it a subject of extensive genetic research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LZTFL1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Lztfl1
Gene Accession No. Q562C6, Q9JHQ5, Q9NQ48
Gene Alias 5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; fb53f12; leucine zipper transcription factor like 1; leucine zipper transcription factor-like 1; leucine zipper transcription factor-like protein 1; LZTFL1; wu:fb53f12; zgc:56268
Gene Symbols Lztfl1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human LZTFL1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 316102, 54585, 93730
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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