Invitrogen™ LZTFL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5118040

Catalog No. PIPA5118040

Description

LZTFL1 Polyclonal Antibody for Western Blot, IHC (P), IP

LZTFL1, also known as Leucine Zipper Transcription Factor-Like 1, is situated on the chromosomal region 3p21.3, which is frequently deleted in various cancers, including kidney cancer. It acts as a tumor suppressor by destabilizing AKT, a key protein in cell growth pathways, thus inhibiting tumor cell growth. Additionally, LZTFL1 has been implicated in the epithelial-mesenchymal transition in COVID-19, suggesting a role in viral response pathways. It is associated with Bardet-Biedl syndrome (BBS) and interacts with IFT27, a regulator of sperm flagellum formation, affecting spermatogenesis and male fertility. Knockout models show a phenotype of obesity, retinal degeneration, and abnormal cilia development, highlighting its role in normal ciliary function. The gene has two transcript isoforms and is part of a transcriptional map covering 250 kb, making it a subject of extensive genetic research.

Specifications

• Antigen: LZTFL1
• Classification: Polyclonal
• Formulation: PBS with 0.03% ProClin 300; pH 7
• Gene Accession No.: Q9NQ48
• Gene Symbols: Lztfl1
• Immunogen: E. coli-derived Human LZTFL1 fragment.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Gene: Lztfl1
• Gene Alias: 5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; fb53f12; leucine zipper transcription factor like 1; leucine zipper transcription factor-like 1; leucine zipper transcription factor-like protein 1; LZTFL1; wu:fb53f12; zgc:56268
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 54585
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid