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Invitrogen™ LZTFL1 Polyclonal Antibody
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Catalog No. PIPA543167
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100 μL
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PIPA543167 100 μL
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Catalog No. PIPA543167 Supplier Invitrogen™ Supplier No. PA543167
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Description

Rabbit Polyclonal Antibody

Peptide sequence: VQEQLHMAEK ELEKKFQQTA AYRNMKEILT KKNDQIKDLR KRLAQYEPED Sequence homology: Cow: 100%; Dog: 86%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 92%.

LZTFL1, also known as Leucine Zipper Transcription Factor-Like 1, is situated on the chromosomal region 3p21.3, which is frequently deleted in various cancers, including kidney cancer. It acts as a tumor suppressor by destabilizing AKT, a key protein in cell growth pathways, thus inhibiting tumor cell growth. Additionally, LZTFL1 has been implicated in the epithelial-mesenchymal transition in COVID-19, suggesting a role in viral response pathways. It is associated with Bardet-Biedl syndrome (BBS) and interacts with IFT27, a regulator of sperm flagellum formation, affecting spermatogenesis and male fertility. Knockout models show a phenotype of obesity, retinal degeneration, and abnormal cilia development, highlighting its role in normal ciliary function. The gene has two transcript isoforms and is part of a transcriptional map covering 250 kb, making it a subject of extensive genetic research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LZTFL1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Lztfl1
Gene Accession No. Q9NQ48
Gene Alias 5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; fb53f12; leucine zipper transcription factor like 1; leucine zipper transcription factor-like 1; leucine zipper transcription factor-like protein 1; LZTFL1; wu:fb53f12; zgc:56268
Gene Symbols Lztfl1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human LZTFL1 (aa 250-299).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54585
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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